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Leramistat - Istesso

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Drug Profile

Leramistat - Istesso

Alternative Names: JNJ-7752; MBS-2320

Latest Information Update: 28 Mar 2025

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At a glance

  • Originator University of Aberdeen
  • Developer Istesso
  • Class Anti-inflammatories; Antifibrotics; Antineoplastics; Antirheumatics; Small molecules
  • Mechanism of Action Tumour necrosis factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Rheumatoid arthritis
  • Phase I Idiopathic pulmonary fibrosis
  • No development reported Autoimmune disorders
  • Discontinued Multiple myeloma; Ulcerative colitis

Most Recent Events

  • 28 Mar 2025 No recent reports of development identified for phase-I development in Autoimmune-disorders in United Kingdom (PO)
  • 12 Apr 2024 Modern Biosciences plans a pharmacokinetics phase I trial (In volunteers) in United Kingdom (PO, Capsule) (NCT06379958)
  • 08 Apr 2024 Modern Biosciences initiates enrolment in a pharmacokinetics phase I trial (In volunteers) in United Kingdom (PO, Capsule) (NCT06379958)

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