Amivantamab - Genmab/Janssen Biotech
Alternative Names: Ami-LC-MD; Amivantamab admixed with rHuPH20; Amivantamab-vmjw; Bispecific EGFR-cMet antibody; CNTO4424; EGFR-MET bispecific antibody; EGFRxcMET bispecific antibody; JNJ 372; JNJ-61186372; JNJ-6372; RYBREVANTLatest Information Update: 27 Sep 2024
At a glance
- Originator Genmab; Janssen Biotech
- Developer Janssen Biotech; Janssen Research & Development; Memorial Sloan-Kettering Cancer Center
- Class Antineoplastics; Bispecific antibodies; Immunotherapies
- Mechanism of Action Antibody-dependent cell cytotoxicity
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Marketed Non-small cell lung cancer
- Phase II Gastric cancer; Liver cancer; Oesophageal cancer
- Phase I/II Colorectal cancer; Squamous cell cancer
- Phase I Solid tumours
Most Recent Events
- 27 Sep 2024 Launched for Non-small cell lung cancer (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV)
- 19 Sep 2024 Registered for Non-small cell lung cancer (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV)
- 19 Sep 2024 Updated efficacy and adverse events data from the phase III MARIPOSA-2 trial in Non-small cell lung cancer released by Johnson & Johnson