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Amivantamab - Genmab/Janssen Biotech

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Drug Profile

Amivantamab - Genmab/Janssen Biotech

Alternative Names: Ami-LC-MD; Amivantamab admixed with rHuPH20; Amivantamab-vmjw; Bispecific EGFR-cMet antibody; CNTO4424; EGFR-MET bispecific antibody; EGFRxcMET bispecific antibody; JNJ 372; JNJ-61186372; JNJ-6372; RYBREVANT

Latest Information Update: 27 Sep 2024

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At a glance

  • Originator Genmab; Janssen Biotech
  • Developer Janssen Biotech; Janssen Research & Development; Memorial Sloan-Kettering Cancer Center
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase II Gastric cancer; Liver cancer; Oesophageal cancer
  • Phase I/II Colorectal cancer; Squamous cell cancer
  • Phase I Solid tumours

Most Recent Events

  • 27 Sep 2024 Launched for Non-small cell lung cancer (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV)
  • 19 Sep 2024 Registered for Non-small cell lung cancer (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV)
  • 19 Sep 2024 Updated efficacy and adverse events data from the phase III MARIPOSA-2 trial in Non-small cell lung cancer released by Johnson & Johnson

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