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Milvexian - Bristol-Myers Squibb/Johnson & Johnson Innovative Medicine

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Drug Profile

Milvexian - Bristol-Myers Squibb/Johnson & Johnson Innovative Medicine

Alternative Names: BMS 177; BMS-986177; JNJ-3093; JNJ-70033093

Latest Information Update: 27 Nov 2025

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At a glance

  • Originator Bristol-Myers Squibb
  • Developer Bristol-Myers Squibb; Johnson & Johnson Innovative Medicine
  • Class Antiarrhythmics; Antithrombotics; Aza compounds; Cardiovascular therapies; Chlorobenzenes; Fluorine compounds; Macrocyclic compounds; Pyrimidinones; Small molecules; Triazoles; Vascular disorder therapies
  • Mechanism of Action Factor XIa inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute coronary syndromes; Atrial fibrillation; Stroke
  • Discontinued Venous thromboembolism

Most Recent Events

  • 14 Nov 2025 Bristol-Myers Squibb terminates a phase III LIBREXIA-ACS trial in Acute coronary syndrome in US, Argentina, Australia, Austria, Belgium, Brazil, Bulgaria, Canada, Chile, China, Croatia, Czech Republic, Denmark, France, Germany, Greece, Hungary, India, Israel, Italy, Japan, South Korea, Latvia, Lithuania, Malaysia, Mexico, Netherlands, New Zealand, Poland, Portugal, Romania, Serbia, Slovakia, South Africa, Spain, Switzerland, Taiwan, Thailand, Turkey, and United Kingdom because the trial is not likely to meet primary endpoint
  • 08 Sep 2024 Pharmacokinetics, pharmacodynamics and adverse event data from a phase I trial in healthy volunteers presented at the American College of Clinical Pharmacology Annual Meeting (ACCP-2024)
  • 30 Aug 2024 Pharmacokinetics and pharmacodynamics data from the AXIOMATIC-TKR phase II trial in Venous thromboembolism presented at the annual congress of the European Society of Cardiology (ESC-Card-2024)

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