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Lonodelestat - Santhera Pharmaceuticals

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Drug Profile

Lonodelestat - Santhera Pharmaceuticals

Alternative Names: POL-6014

Latest Information Update: 19 Jul 2023

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At a glance

  • Originator Polyphor
  • Developer Santhera Pharmaceuticals
  • Class Antibronchitics; Antifibrotics; Macrocyclic compounds; Peptides; Small molecules
  • Mechanism of Action Leucocyte elastase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Primary ciliary dyskinesia; Alpha 1-antitrypsin deficiency; Cystic fibrosis
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Cystic fibrosis
  • Phase I Alpha 1-antitrypsin deficiency; Primary ciliary dyskinesia
  • Preclinical Respiration disorders
  • No development reported Bronchiectasis; Chronic obstructive pulmonary disease

Most Recent Events

  • 30 Apr 2023 Lonodelestat is still in phase-I trials for Alpha-1-antitrypsin-deficiency in Switzerland (Inhalation)
  • 30 Apr 2023 Phase-I clinical trials in Primary ciliary dyskinesia in Switzerland (Inhalation)
  • 27 Apr 2023 Santhera Pharmaceuticals plans a phase II trial for Adult-respiratory-distress-syndrome in Unknown location

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