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Fosmanogepix - Basilea Pharmaceutica

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Drug Profile

Fosmanogepix - Basilea Pharmaceutica

Alternative Names: APX-001; E-1211; E-210; PF-07842805

Latest Information Update: 04 Aug 2025

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At a glance

  • Originator Eisai Co Ltd
  • Developer Amplyx Pharmaceuticals; Basilea Pharmaceutica
  • Class Aminopyridines; Antifungals; Antineoplastics; Oxazoles; Phosphates; Small molecules
  • Mechanism of Action GWT1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Coccidioidomycosis; Candidiasis; Mycoses; Cryptococcosis; Aspergillosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Candidaemia; Mycoses
  • Phase II Aspergillosis
  • No development reported Acute myeloid leukaemia; Coccidioidomycosis

Most Recent Events

  • 29 Jul 2025 Phase-III clinical trials in Mycoses in USA (IV) (NCT06925321)
  • 29 Jul 2025 Phase-III clinical trials in Mycoses in USA (PO) (NCT06925321)
  • 15 Jul 2025 Basilea Pharmaceutica completes a phase pharmacokinetics trial for Healthy volunteers in China (PO, IV) (NCT06961708)

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