Research programme : anti-fibrotic therapeutics - ProMetic Life Sciences

Drug Profile

Research programme : anti-fibrotic therapeutics - ProMetic Life Sciences

Alternative Names: PBI-4425; PBI-4547

Latest Information Update: 17 Aug 2017

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At a glance

  • Originator ProMetic Life Sciences
  • Class Antifibrotics; Antihyperglycaemics; Small molecules
  • Mechanism of Action Cell differentiation modulators; Collagen inhibitors; Colony stimulating factor stimulants; Cytokine modulators; Erythropoiesis stimulants; Extracellular matrix protein inhibitors; Immunomodulators; Inflammation mediator modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Diabetic nephropathies; Hepatic fibrosis; Idiopathic pulmonary fibrosis; Scleroderma

Most Recent Events

  • 20 Feb 2018 Prometic Life Sciences plans a phase I trial for PBI 4547 for Non-alcoholic steatohepatitis in Q2 2018
  • 20 Feb 2018 ProMetic plans a phase II trial for Liver fibrosis and Metabolic disorders in Q2 2018
  • 14 Aug 2017 PBI 4547, PBI 4425 licensed to Prometic ChinaCo for development in China
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