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Zilucoplan - UCB

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Drug Profile

Zilucoplan - UCB

Alternative Names: RA 101495; RA101495 SC; ZILBRYSQ; Zilbrysq; ZLP-AI

Latest Information Update: 17 Dec 2024

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At a glance

  • Originator Ra Pharmaceuticals
  • Developer Ra Pharmaceuticals; UCB
  • Class Antianaemics; Antivirals; Cyclic peptides; Lactams; Macrocyclic compounds; Urologics
  • Mechanism of Action Complement C5 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Paroxysmal nocturnal haemoglobinuria; Myasthenia gravis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Myasthenia gravis
  • Phase III COVID 2019 infections
  • Phase II/III Amyotrophic lateral sclerosis
  • Discontinued Haemolytic uraemic syndrome; Immune-mediated necrotising myopathy; Lupus nephritis; Paroxysmal nocturnal haemoglobinuria; Respiratory insufficiency; Unspecified

Most Recent Events

  • 26 Nov 2024 UCB Biopharma completes a phase-I bioequivalence trial (In volunteers) in Netherlands (SC), (NCT06511076),
  • 19 Nov 2024 Phase-III clinical trials in Myasthenia gravis (In children, In adolescents, In adults, In the elderly) in United Kingdom, South Korea, Italy, USA (SC) (NCT06435312)
  • 23 Oct 2024 UCB Biopharma complete a phase-III trial in Myasthenia gravis (In adults, In the elderly, Treatment-experienced) in USA (SC) (NCT05514873)

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