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Zilucoplan - UCB

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Drug Profile

Zilucoplan - UCB

Alternative Names: RA 101495; RA101495 SC; ZILBRYSQ; Zilbrysq; ZLP-AI

Latest Information Update: 30 Aug 2024

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At a glance

  • Originator Ra Pharmaceuticals
  • Developer Ra Pharmaceuticals; UCB
  • Class Antianaemics; Antivirals; Cyclic peptides; Lactams; Macrocyclic compounds; Urologics
  • Mechanism of Action Complement C5 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Paroxysmal nocturnal haemoglobinuria; Myasthenia gravis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Myasthenia gravis
  • Phase III COVID 2019 infections
  • Phase II/III Amyotrophic lateral sclerosis
  • Discontinued Haemolytic uraemic syndrome; Immune-mediated necrotising myopathy; Lupus nephritis; Paroxysmal nocturnal haemoglobinuria; Respiratory insufficiency; Unspecified

Most Recent Events

  • 05 Aug 2024 UCB Biopharma initiates phase I bioequivalence trial (In volunteers) (SC) in Netherlands (NCT06511076)
  • 19 Jul 2024 UCB Biopharma plans a phase I bioequivalence trial for Myasthenia gravis (In volunteers) in August 2024 (SC) (NCT06511076)
  • 17 Jul 2024 Registered for Myasthenia gravis (In adults) in Canada (SC)

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