NKTR 214

Drug Profile

NKTR 214

Alternative Names: NKTR-214

Latest Information Update: 03 Jul 2018

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At a glance

  • Originator Nektar Therapeutics; University of Texas M. D. Anderson Cancer Center
  • Developer Bristol-Myers Squibb; Nektar Therapeutics; Takeda; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Cytokines
  • Mechanism of Action CD8 positive T lymphocyte stimulants; Natural killer cell stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Sarcoma
  • Phase I/II Bladder cancer; Colorectal cancer; Malignant melanoma; Non-small cell lung cancer; Renal cell carcinoma; Solid tumours
  • Preclinical Lymphoma

Most Recent Events

  • 26 Jun 2018 IsoPlexis Corporation and Nektar Therapeutics agree to co-develop NKTR 214 in the US for Cancer
  • 02 Jun 2018 Preliminary efficacy and adverse events data from the phase I dose escalation portion and phase II dose expansion cohorts of the phase I/II PIVOT trial in Solid tumours presented at the American Society of Clinical Oncology (ASCO-2018)
  • 01 Jun 2018 Pharmacodynamics data from a preclinical trial in Colon cancer model in combination with TAK 659 presented at the 54th Annual Meeting of the American Society of Clinical Oncology
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