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Zatolmilast - Tetra Therapeutics

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Drug Profile

Zatolmilast - Tetra Therapeutics

Alternative Names: BPN-14770

Latest Information Update: 12 Sep 2025

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At a glance

  • Originator Tetra Discovery Partners
  • Developer Shionogi; Tetra Therapeutics
  • Class Acetamides; Amines; Antidementias; Benzeneacetamides; Chlorobenzenes; Fluorinated hydrocarbons; Pyrimidines; Small molecules
  • Mechanism of Action Type 4 cyclic nucleotide phosphodiesterase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Fragile X syndrome
  • New Molecular Entity Yes
  • Available For Licensing Yes - Alzheimer's disease; Cognition disorders

Highest Development Phases

  • Phase II/III Fragile X syndrome
  • Phase II Alzheimer's disease; Neurodevelopmental disorders

Most Recent Events

  • 30 Aug 2025 Shionogi initiates enrolment in a phase I Pharmacokinetics trial in USA (PO) (NCT07018492)
  • 07 Aug 2025 Shionogi completes a phase I pharmacokinetics trial (In volunteers) in USA (PO) (NCT07011992)
  • 18 Jul 2025 Shionogi initiates a phase I pharmacokinetics trial (In volunteers) in USA (PO) (NCT07011992)

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