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Zatolmilast - Tetra Therapeutics

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Drug Profile

Zatolmilast - Tetra Therapeutics

Alternative Names: BPN-14770

Latest Information Update: 18 Feb 2025

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At a glance

  • Originator Tetra Discovery Partners
  • Developer Tetra Therapeutics
  • Class Acetamides; Amines; Antidementias; Benzeneacetamides; Chlorobenzenes; Fluorinated hydrocarbons; Pyrimidines; Small molecules
  • Mechanism of Action Type 4 cyclic nucleotide phosphodiesterase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Fragile X syndrome
  • New Molecular Entity Yes
  • Available For Licensing Yes - Alzheimer's disease; Cognition disorders

Highest Development Phases

  • Phase II/III Fragile X syndrome
  • Phase II Alzheimer's disease

Most Recent Events

  • 18 Feb 2025 Phase II/III development is ongoing in Fragile X syndrome in USA
  • 04 Feb 2025 Zatolmilast receives Rare Pediatric Disease Designation from the U.S. FDA for Neurodevelopmental disorders in USA
  • 12 Dec 2024 Shionogi in collaboration with Jordan’s Guardian Angels plans a phase II trial for Neurodevelopmental disorders (In children, In adolescents, In adults) in USA (PO), in January 2025 (NCT06717438)

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