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Glecaprevir/pibrentasvir - AbbVie

Drug Profile

Glecaprevir/pibrentasvir - AbbVie

Alternative Names: 2DAA; ABT-493/ABT-530; GLE/PIB; Glecaprevir Hydrate/Pibrentasvir - AbbVie; HCV Next Gen; MAVIRET; MAVYRET; Pibrentasvir/glecaprevir; Pibrentasvir/glecaprevir-Abbvie

Latest Information Update: 08 Jun 2021

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At a glance

  • Originator AbbVie; Enanta Pharmaceuticals
  • Developer AbbVie
  • Class Antivirals; Aza compounds; Benzimidazoles; Carbamates; Cyclic ethers; Cyclopentanes; Cyclopropanes; Fluorobenzenes; Piperidines; Pyrrolidines; Quinoxalines; Small molecules
  • Mechanism of Action Hepatitis C virus NS 5 protein inhibitors; Hepatitis C virus NS3 protein inhibitors; Hepatitis C virus NS4 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Marketed Hepatitis C

Most Recent Events

  • 26 May 2021 AbbVie plans a phase III trial for Hepatitis C (In adults, In adolescents) in US, Australia, Austria, Spain, Germany and Italy in June 2021 (PO, Tablet) (NCT04903626) (EudraCT2020-005777-27)
  • 08 Jul 2020 AbbVie initiates enrolment in a phase I bioavailability trial in USA (EudraCT2019-003736-22)
  • 06 Mar 2020 The European Commission approves marketing authorisation of glecaprevir/pibrentasvir to shorten once-daily treatment duration from 12 to 8 weeks for Compensated cirrhotic, chronic Hepatitis C (Treatment-naive) patients with genotype (GT) 3 infection
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