Trigriluzole - Biohaven Pharmaceutical

Drug Profile

Trigriluzole - Biohaven Pharmaceutical

Alternative Names: BHV-4157; FC 4157

Latest Information Update: 30 Jan 2018

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At a glance

  • Originator Yale University
  • Developer Biohaven Pharmaceutical Holding Company; National Cancer Institute (USA); Rutgers Cancer Institute of New Jersey
  • Class Antineoplastics; Benzothiazoles; Small molecules
  • Mechanism of Action Glutamate modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Spinocerebellar degeneration
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Spinocerebellar degeneration
  • Phase II/III Obsessive-compulsive disorders
  • Phase I Lymphoma; Solid tumours

Most Recent Events

  • 21 Dec 2017 Phase-II/III clinical trials in Obsessive-compulsive disorders (Treatment-experienced, Adjunctive treatment) in USA (PO) (NCT03299166)
  • 15 Dec 2017 Phase-III clinical trials in Spinocerebellar degeneration in USA (PO) (NCT03408080)
  • 30 Oct 2017 Biohaven Pharmaceutical Holding Company enters into a clinical collaboration agreement with the Rutgers Cancer Institute of New Jersey to evaluate trigriluzole in combination with PD-1 blocking antibodies in patients with inoperable, advanced or refractory cancers
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