Fluorine-18-THK 5351

Drug Profile

Fluorine-18-THK 5351

Alternative Names: [18F]THK-5351; F-18 THK-5351; FluoroTau; GE-216

Latest Information Update: 17 Oct 2017

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At a glance

  • Originator Tohoku University
  • Developer Fundacio Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau; GE Healthcare; Tohoku University
  • Class Antidementias; Imaging agents; Pyridines; Quinolines; Radiopharmaceutical diagnostics; Small molecules
  • Mechanism of Action Positron-emission tomography enhancers
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alzheimer's disease; Neurodegenerative disorders
  • Clinical Phase Unknown Aphasia; Lewy body disease; Mild cognitive impairment; Progressive supranuclear palsy

Most Recent Events

  • 13 Feb 2018 Chang Gung Memorial Hospital plans a phase II trial for Major depressive disorder (Diagnosis) in March 2018 , (NCT03430869)
  • 10 Oct 2017 Phase-II clinical trials in Neurodegenerative disorders (Diagnosis) in Spain (IV) (EudraCT2015-004656-22)
  • 24 Aug 2017 Chemical structure information added
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