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Galicaftor - AbbVie/Galapagos NV

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Drug Profile

Galicaftor - AbbVie/Galapagos NV

Alternative Names: ABBV 2222; GLPG-2222; SION-2222

Latest Information Update: 26 Sep 2025

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At a glance

  • Originator Cystic Fibrosis Foundation Therapeutics; Galapagos NV
  • Developer AbbVie; Galapagos NV; Sionna Therapeutics
  • Class Amides; Antifibrotics; Benzoic acids; Chromans; Cyclopropanes; Dioxolanes; Fluorinated hydrocarbons; Small molecules
  • Mechanism of Action Cystic fibrosis transmembrane conductance regulator modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Cystic fibrosis

Most Recent Events

  • 25 Aug 2025 Phase-I clinical trials in Cystic fibrosis (In volunteers, Combination therapy) in Australia (PO) (NCT07035990)
  • 26 Jun 2025 Sionna Therapeutics plans a phase I trial for Cystic fibrosis (In volunteers, In adults, Combination therapy) in Australia (PO, Capsule), in July 2025 (NCT07035990)
  • 06 Jun 2025 Pharmacodynamics data from a preclinical study in Cystic fibrosis released in Sionna Therapeutics

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