TTI 621

Drug Profile

TTI 621

Alternative Names: CD47 antigen/SIRPalpha protein modulator - Trillium Therapeutics; SIRPaFc; SIRPalphaFc; TTI-621

Latest Information Update: 20 Aug 2018

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At a glance

  • Originator The Hospital for Sick Children; University Health Network
  • Developer Trillium Therapeutics Inc
  • Class Antineoplastics; Immunoglobulin Fc fragments; Immunoglobulin fusion proteins; Recombinant fusion proteins
  • Mechanism of Action CD47 antigen inhibitors; SIRPA protein stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cutaneous T cell lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Haematological malignancies; Mycosis fungoides; Sezary syndrome; Small cell lung cancer; Solid tumours

Most Recent Events

  • 20 Mar 2018 TTI 621 receives Orphan drug status for Cutaneous T-cell lymphoma in USA
  • 11 Dec 2017 Efficacy and adverse events data from phase I trials in Haematological malignancies and Mycosis fungoides released by Trillium
  • 09 Dec 2017 Efficacy and adverse events data from a phase I trial in Solid tumours and Mycosis fungoides presented at the 59th Annual Meeting and Exposition of the American Society of Hematology (ASH-Hem-2017)
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