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Ontorpacept - Trillium Therapeutics

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Drug Profile

Ontorpacept - Trillium Therapeutics

Alternative Names: CD47 antigen/SIRPalpha protein modulator - Trillium Therapeutics; SIRPaFc; SIRPalphaFc; TTI-621

Latest Information Update: 28 Jun 2025

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At a glance

  • Originator The Hospital for Sick Children; University Health Network
  • Developer Trillium Therapeutics Inc
  • Class Antineoplastics; Immunoglobulin Fc fragments; Immunoglobulin fusion proteins; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action CD47 antigen inhibitors; Phagocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cutaneous T-cell lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Leiomyosarcoma
  • No development reported Haematological malignancies; Multiple myeloma; Mycosis fungoides; Sezary syndrome; Small cell lung cancer; Solid tumours

Most Recent Events

  • 28 Jun 2025 No recent reports of development identified for phase-I development in Haematological-malignancies(Combination therapy, Late-stage disease, Second-line therapy or greater) in Canada (IV)
  • 28 Jun 2025 No recent reports of development identified for phase-I development in Haematological-malignancies(Combination therapy, Late-stage disease, Second-line therapy or greater) in USA (IV)
  • 28 Jun 2025 No recent reports of development identified for phase-I development in Haematological-malignancies(Late-stage disease, Monotherapy, Second-line therapy or greater) in Canada (IV)

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