MB 66

Drug Profile

MB 66

Alternative Names: HIV/HSV microbicide - Mapp; Mapp 66; MB66

Latest Information Update: 20 Apr 2018

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At a glance

  • Originator Mapp Biopharmaceutical
  • Developer Boston University; Integrated Preclinical/Clinical Program for HIV Topical Microbicides Consortium; Mapp Biopharmaceutical; The Miriam Hospital
  • Class Antivirals; Monoclonal antibodies
  • Mechanism of Action HIV envelope protein gp120 inhibitors; HIV envelope protein gp41 inhibitors; HIV fusion inhibitors; Viral fusion protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Herpes simplex virus infections; HIV infections

Most Recent Events

  • 20 Apr 2018 Phase-I development in Herpes simplex virus infections prevention is ongoing in USA (Vaginal) (NCT02579083; 3316886)
  • 04 Mar 2018 Efficacy and adverse events data from the phase I VAST trial in Herpes simplex virus infections prevention and HIV infections presented at the 25th Conference on Retroviruses and Opportunistic Infections (CROI-2018)
  • 28 Feb 2018 No recent reports of development identified for phase-I development in Herpes-simplex-virus-infections in USA (Vaginal, Film)
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