Drug Profile

Loncastuximab tesirine - ADC Therapeutics

Alternative Names: ADCT-402; Anti-CD19-PBD-conjugate-ADC; Lonca; Lonca-T; loncastuximab tesirine-lpyl; MT-2111; ZYNLONTA

Latest Information Update: 11 Dec 2025

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At a glance

Originator ADC Therapeutics; Spirogen
Developer ADC Therapeutics; Swedish Orphan Biovitrum; Tanabe Pharma Corporation
Class Antineoplastics; Benzodiazepines; Drug conjugates; Immunotoxins; Monoclonal antibodies; Pyrroles
Mechanism of Action Alkylating agents; DNA cross linking agents

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Mantle-cell lymphoma; Diffuse large B cell lymphoma
New Molecular Entity Yes

Marketed Diffuse large B cell lymphoma
Preregistration B-cell lymphoma
Phase II Follicular lymphoma; Marginal zone B-cell lymphoma; Waldenstrom's macroglobulinaemia
Phase I/II Mantle-cell lymphoma
Phase I Non-Hodgkin's lymphoma
Discontinued Precursor B-cell lymphoblastic leukaemia-lymphoma

01 Dec 2025 Mitsubishi Tanabe Pharma Corporation is now called Tanabe Pharma Corporation
10 Nov 2025 Efficacy and adverse event data from a phase II trial in Follicular lymphoma released by ADC Therapeutics
13 Oct 2025 ADC Therapeutics plans to relaunch Loncastuximab tesirine in 2027

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