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Loncastuximab tesirine - ADC Therapeutics

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Drug Profile

Loncastuximab tesirine - ADC Therapeutics

Alternative Names: ADCT-402; Anti-CD19-PBD-conjugate-ADC; Lonca; Lonca-T; loncastuximab tesirine-lpyl; MT-2111; ZYNLONTA

Latest Information Update: 31 Aug 2026

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At a glance

  • Originator ADC Therapeutics; Spirogen
  • Developer ADC Therapeutics; Swedish Orphan Biovitrum; Tanabe Pharma Corporation
  • Class Antineoplastics; Benzodiazepines; Drug conjugates; Immunoconjugates; Immunotoxins; Monoclonal antibodies; Pyrroles
  • Mechanism of Action Alkylating agents; DNA cross linking agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mantle-cell lymphoma; Diffuse large B cell lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Diffuse large B cell lymphoma
  • Preregistration B-cell lymphoma
  • Phase II Follicular lymphoma; Marginal zone B-cell lymphoma; Waldenstrom's macroglobulinaemia
  • Phase I/II Mantle-cell lymphoma
  • Phase I Non-Hodgkin's lymphoma
  • Discontinued Precursor B-cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 13 Aug 2026 ADC Therapeutics announces intention to submit application for Breakthrough Therapy designation to the US FDA for Diffuse large B-cell lymphoma and Marginal zone B-cell lymphoma (Combination therapy) in 2026
  • 13 Aug 2026 ADC Therapeutics held a pre-sBLA meeting with US FDA for Loncastuximab tesirine for Diffuse large B-cell lymphoma (Combination therapy, Second-line therapy or greater)
  • 13 Aug 2026 ADC Therapeutics plans a clinical trial for Diffuse large B cell lymphoma (Combination therapy, First-line therapy)

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