Drug Profile

Retifanlimab - Incyte Corporation/MacroGenics

Alternative Names: AEX-1188; INCMGA-0012; INCMGA00012; MGA-012; Retifanlimab-dlwr; Zynyz

Latest Information Update: 14 Apr 2026

Price :

$50 ^*

Note:

Adis is an information provider. We do not sell or distribute actual drugs.
Final gross price and currency may vary according to local VAT and billing address.
Your purchase entitles you to full access to the information contained in our drug profile at the time of purchase.
A link to download a PDF version of the drug profile will be included in your email receipt.

At a glance

Originator MacroGenics
Developer BriaCell Therapeutics Corp; Incyte Corporation; MacroGenics; University of Washington; ZAI Lab
Class Antineoplastics; Immunotherapies; Monoclonal antibodies
Mechanism of Action Antibody-dependent cell cytotoxicity; Programmed cell death 1 receptor antagonists; T lymphocyte stimulants

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Anal cancer; Merkel cell carcinoma
New Molecular Entity Yes

Marketed Merkel cell carcinoma; Squamous cell cancer
Phase III Breast cancer; Endometrial cancer; Non-small cell lung cancer
Phase II Adenosquamous carcinoma; Bladder cancer; Gastric cancer; Glioblastoma; Glioma; Head and neck cancer; Liposarcoma; Oesophageal cancer; Penile cancer; Sarcoma; Solid tumours; Triple negative breast cancer
Phase I/II Colorectal cancer; Malignant melanoma; Soft tissue sarcoma
No development reported Acute myeloid leukaemia; Adenocarcinoma; Haematological malignancies

14 Apr 2026 Phase-II clinical trials in Squamous cell cancer (First-line therapy, Recurrent, Monotherapy, Metastatic disease) in Poland, Canada, France, Germany, Italy and South Korea (IV) (NCT05287113)
28 Mar 2026 No recent reports of development identified for phase-I development in Adenocarcinoma(Combination therapy, Metastatic disease, Second-line therapy or greater) in USA (IV)
28 Mar 2026 No recent reports of development identified for phase-I development in Glioblastoma(Combination therapy, First-line therapy) in USA (IV, Infusion)

If your organization or you do not have a subscription, try one of the following:

Contacting your organization’s admin about adding this content to your AdisInsight subscription
Buying a PDF version of any individual profile
Request a free trial (opens in a new window)

If your organization has a subscription, there are several access options, even while working remotely:

Working within your organization’s network
Login with username/password or try to access via your institution
Persisted access using your organization’s identifier stored in your user browser for 90 days

For assistance, contact us at asktheexpert.adisinsight@springer.com