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Izokibep - Affibody

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Drug Profile

Izokibep - Affibody

Alternative Names: ABY 035; ABY-035/AFO2; AFB-035; IMG-020; IMG-20

Latest Information Update: 02 Jun 2025

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At a glance

  • Originator Affibody
  • Developer ACELYRIN; Affibody; Alumis
  • Class Anti-inflammatories; Antipsoriatics; Antirheumatics; Recombinant fusion proteins
  • Mechanism of Action IL17A protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Ankylosing spondylitis; Axial spondyloarthritis; Hidradenitis suppurativa; Plaque psoriasis; Psoriasis; Psoriatic arthritis; Uveitis

Most Recent Events

  • 21 May 2025 ACELYRIN has merged with Alumis to form Alumis
  • 28 Apr 2025 Discontinued - Phase-I for Plaque psoriasis in USA (unspecified route)
  • 28 Apr 2025 Discontinued - Phase-I/II for Psoriasis in United Kingdom (SC, IV) due to lack of efficacy

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