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Pegrizeprument - Veloxis Pharmaceuticals

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Drug Profile

Pegrizeprument - Veloxis Pharmaceuticals

Alternative Names: Anti CD28 monoclonal antibody - OSE Therapeutics; FR-104; VEL-101

Latest Information Update: 30 Apr 2026

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At a glance

  • Originator Effimune
  • Developer Biomedical Primate Research Center; Janssen Biotech; Nantes University Hospital; OSE Immunotherapeutics; Veloxis Pharmaceuticals
  • Class Anti-inflammatories; Antipsoriatics; Antirheumatics; Eye disorder therapies; Fab fragments; Monoclonal antibodies
  • Mechanism of Action CD28 antigen inhibitors; T lymphocyte inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Heart transplant rejection; Liver transplant rejection
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Transplant rejection
  • No development reported Encephalomyelitis; Multiple sclerosis; Psoriasis; Rheumatoid arthritis; Uveitis

Most Recent Events

  • 22 Apr 2026 Pegrizeprument - Veloxis Pharmaceuticals receives Orphan Drug status for Heart transplant rejection (Prevention) in USA
  • 21 Jan 2026 Pegrizeprument - Veloxis Pharmaceuticals receives Orphan Drug status for Liver transplant rejection (Prevention) in USA
  • 18 Jan 2026 Veloxis Pharmaceuticals plans a phase II RENGEVITY-201 trial for Transplant rejection (Prevention) in July 2026 (Parenteral) (NCT07290777)

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