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SPL 334

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Drug Profile

SPL 334

Alternative Names: GSNORi - SAJE Pharma; SPL-334; SPL-334.1

Latest Information Update: 28 Aug 2025

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At a glance

  • Originator Johns Hopkins University
  • Developer SAJE Pharma
  • Class Anti-inflammatories; Antiasthmatics; Antifibrotics; Heart failure therapies; Hepatoprotectants; Small molecules
  • Mechanism of Action Glutathione-independent formaldehyde dehydrogenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Asthma; Idiopathic pulmonary fibrosis; Inflammation; Parkinson's disease

Highest Development Phases

  • Preclinical Inflammation; Myocardial infarction; Non-alcoholic fatty liver disease
  • No development reported Asthma; Idiopathic pulmonary fibrosis
  • Discontinued Parkinson's disease

Most Recent Events

  • 28 Aug 2025 No recent reports of development identified for preclinical development in Asthma in USA (PO)
  • 28 Aug 2025 No recent reports of development identified for preclinical development in Idiopathic-pulmonary-fibrosis in USA (PO)
  • 28 Aug 2025 No recent reports of development identified for preclinical development in Inflammation in USA (Intraperitoneal, Injection)

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