Hu5F9 G4

Drug Profile

Hu5F9 G4

Alternative Names: 5F9; Hu5F9-G4

Latest Information Update: 21 Aug 2018

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At a glance

  • Originator Stanford University
  • Developer Forty Seven; Merck KGaA; Stanford University
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action CD47 antigen inhibitors; SIRPA protein modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Colorectal cancer; Diffuse large B cell lymphoma; Follicular lymphoma; Non-Hodgkin's lymphoma; Solid tumours
  • Phase I Acute myeloid leukaemia; Myelodysplastic syndromes; Ovarian cancer
  • No development reported Lymphoma

Most Recent Events

  • 13 Aug 2018 Additional efficacy data from a phase I/II trial in Non-Hodgkin's lymphoma, Diffuse large B cell lymphoma, and Follicular lymphoma (Combination therapy, Second-line therapy or greater) released by Forty Seven
  • 31 Jul 2018 Forty Seven sub-licenses patent pertaining to 5F9 from Synthon Biopharmaceuticals
  • 31 Jul 2018 Forty Seven enters into settlement agreement with Synthon Biopharmaceuticals related to patent pertaining to 5F9
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