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Afimetoran - Bristol-Myers Squibb

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Drug Profile

Afimetoran - Bristol-Myers Squibb

Alternative Names: BMS-986256; TLR 7/8 Antagonist - Bristol-Myers Squibb; TLR 7/8 inhibitor - Bristol-Myers Squibb; Toll-like receptor 7/8 antagonist - Bristol-Myers Squibb

Latest Information Update: 28 Jul 2025

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At a glance

  • Originator Bristol-Myers Squibb
  • Class 2 ring heterocyclic compounds; Acetamides; Antineoplastics; Indoles; Monoclonal antibodies; Piperidines; Pyridines; Skin disorder therapies; Small molecules; Triazoles
  • Mechanism of Action Toll-like receptor 7 antagonists; Toll-like receptor 8 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Systemic lupus erythematosus
  • Phase I Unspecified
  • No development reported Autoimmune disorders
  • Discontinued Cutaneous lupus erythematosus

Most Recent Events

  • 28 Jul 2025 No recent reports of development identified for phase-I development in Autoimmune-disorders in USA (PO)
  • 28 Jul 2025 No recent reports of development identified for phase-I development in Systemic-lupus-erythematosus in USA (PO, Capsule)
  • 12 Jun 2024 Pharmacodynamics, efficacy and adverse events data from a phase Ib trial in Systemic lupus erythematosus presented at the 25th Annual Congress of the European League Against Rheumatism (EULAR-2024)

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