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Lusvertikimab - OSE Immunotherapeutics

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Drug Profile

Lusvertikimab - OSE Immunotherapeutics

Alternative Names: Anti CD127 monoclonal antibody - OSE Immunotherapeutics; Anti interleukin-7 receptor-α monoclonal antibody - OSE Immunotherapeutics; Effi-7; IL-7 receptor alpha antagonist - OSE Immunotherapeutics; OSE-127; S-95011

Latest Information Update: 13 May 2025

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At a glance

  • Originator Effimune
  • Developer OSE Immunotherapeutics; Servier
  • Class Anti-inflammatories; Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Interleukin 7 receptor alpha subunit inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Precursor cell lymphoblastic leukaemia-lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Ulcerative colitis
  • Preclinical Precursor cell lymphoblastic leukaemia-lymphoma
  • Discontinued Crohn's disease; Sjogren's syndrome; Transplant rejection

Most Recent Events

  • 05 May 2025 Updated efficacy and adverse events data from a phase II CoTikiS open-label extension trial in Ulcerative colitis released by OSE Immunotherapeutics
  • 24 Feb 2025 Efficacy and adverse events data from a phase II CoTikiS trial in Ulcerative colitis released by OSE Immunotherapeutics
  • 28 Jan 2025 OSE Immunotherapeutics completes phase II clinical trials in Ulcerative colitis (Treatment-experienced, In adults, In the elderly) in Belarus, Belgium, Bulgaria, Croatia, Georgia, Hungary, Latvia, Poland, Protugal, Russia, South Africa, and Ukraine (IV) (NCT04882007) (EudraCT2020-001398-59)

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