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Lumasiran - Alnylam Pharmaceuticals

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Drug Profile

Lumasiran - Alnylam Pharmaceuticals

Alternative Names: ALN-GO1; Lumasiran; OXLUMO; Oxlumo

Latest Information Update: 21 Feb 2025

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At a glance

  • Originator Alnylam Pharmaceuticals
  • Developer Alnylam Pharmaceuticals; Medison Pharma
  • Class Amino sugars; Drug conjugates; Small interfering RNA; Uricosurics; Urologics
  • Mechanism of Action Glycolate oxidase expression inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Primary hyperoxaluria type 1
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Primary hyperoxaluria type 1
  • Phase II Urinary calculi

Most Recent Events

  • 31 Dec 2024 Registered for Primary hyperoxaluria type 1 in Taiwan, Oman, Argentina (SC) before December 2024
  • 30 Dec 2024 Preregistration for Primary hyperoxaluria type 1 in Oman, Taiwan, Argentina (SC) before December 2024
  • 26 Jul 2024 Alnylam Pharmaceuticals completes phase III clinical trial in Primary hyperoxaluria type 1 (In children, In infants, In neonates) in the USA, Israel, France, United Kingdom, Germany (SC)(NCT03905694) (EudraCT2018-004014-17)

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