Tinostamustine - Mundipharma EDO

Drug Profile

Tinostamustine - Mundipharma EDO

Alternative Names: Bendamustine-vorinostat fusion molecule; EDO S101; NL-101

Latest Information Update: 04 Jan 2018

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At a glance

  • Originator Northlake International
  • Developer Mundipharma EDO
  • Class Antineoplastics; Benzimidazoles; Small molecules
  • Mechanism of Action Alkylating agents; Antimetabolites; Apoptosis stimulants; DNA cross linking agents; Histone deacetylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours
  • Phase I Haematological malignancies

Most Recent Events

  • 09 Mar 2018 Mundipharma EDO and M.D. Anderson Cancer Center plans a phase I trial for Glioblastoma (Newly diagnosed, Second-line therapy or greater) in USA in March 2018 (NCT03452930)
  • 26 Oct 2017 Chemical structure information added
  • 10 Oct 2017 Phase-I/II clinical trials in Solid tumours (Second-line therapy or greater) in USA (IV)
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