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Vafidemstat - Oryzon Genomics

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Drug Profile

Vafidemstat - Oryzon Genomics

Alternative Names: ORY-2001

Latest Information Update: 27 Oct 2025

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At a glance

  • Originator Oryzon
  • Developer Institute of Medical and Molecular Genetics; Oryzon
  • Class Amines; Antidementias; Antiparkinsonians; Antipsychotics; Behavioural disorder therapies; Cyclopropanes; Neuroprotectants; Nootropics; Oxadiazoles; Small molecules
  • Mechanism of Action Lysine specific demethylase 1 inhibitors; Monoamine oxidase B inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Aggression; Alzheimer's disease; Borderline personality disorders; Multiple sclerosis; SARS-CoV-2 acute respiratory disease; Schizophrenia
  • No development reported Autistic disorder; Dementia; Huntington's disease; Parkinson's disease; Telomeric 22q13 Monosomy Syndrome

Most Recent Events

  • 17 Oct 2025 Oryzon Genomics receives a written feedback from the US FDA regarding the Phase III protocol in Borderline personality disorder
  • 22 Sep 2025 Oryzon plans a phase II HOPE-2 trial for Telomeric 22q13 Monosomy Syndrome in the European Union (PO) in 2025
  • 16 Sep 2025 Oryzon Genomics receives patent allowance for Vafidemstat in Europe

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