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Vafidemstat - Oryzon Genomics

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Drug Profile

Vafidemstat - Oryzon Genomics

Alternative Names: ORY-2001

Latest Information Update: 07 Apr 2026

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At a glance

  • Originator Oryzon
  • Developer Institute of Medical and Molecular Genetics; Oryzon
  • Class Amines; Antidementias; Antiparkinsonians; Antipsychotics; Behavioural disorder therapies; Cyclopropanes; Neuroprotectants; Nootropics; Oxadiazoles; Small molecules
  • Mechanism of Action Lysine specific demethylase 1 inhibitors; Monoamine oxidase B inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Aggression; Alzheimer's disease; Borderline personality disorders; Multiple sclerosis; SARS-CoV-2 acute respiratory disease; Schizophrenia
  • No development reported Autistic disorder; Dementia; Huntington's disease; Parkinson's disease; Telomeric 22q13 Monosomy Syndrome

Most Recent Events

  • 25 Mar 2026 Oryzon receives patent allowance for vafidemstat in the US
  • 23 Mar 2026 Oryzon has patent protection for iadademstat combinations with venetoclax in Australia, Brazil, Canada, Europe, India, Israel, Japan, Korea, Malaysia, Mexico, New Zealand, and Russia
  • 23 Mar 2026 Oryzon has patent protection for iadademstat combinations with venetoclax in USA

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