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Evexomostat - SynDevRx

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Drug Profile

Evexomostat - SynDevRx

Alternative Names: MetAP2 inhibitor - SynDevRx; SDX-7320

Latest Information Update: 27 Jun 2023

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At a glance

  • Originator SynDevRx, Inc
  • Developer Memorial Sloan-Kettering Cancer Center; SynDevRx, Inc
  • Class Antineoplastics; Cyclohexanes; Drug conjugates; Sesquiterpenes; Unsaturated fatty acids
  • Mechanism of Action DNA synthesis inhibitors; Methionine aminopeptidase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Triple negative breast cancer
  • Phase I/II Breast cancer
  • Phase I Solid tumours
  • Preclinical Colorectal cancer; Interstitial lung diseases

Most Recent Events

  • 27 Jun 2023 3798119- No significant data, only methods of trial mentioned
  • 14 Apr 2023 Pharmacodynamics data from the preclinical studies in Cancer presented at the 114th Annual Meeting of the American Association for Cancer Research (AACR-2023)
  • 03 Oct 2022 Phase-II clinical trials in Triple-negative-breast cancer (Combination therapy, Metastatic disease, Second-line therapy or greater) in USA (SC) (NCT05570253)

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