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Mobocertinib - Takeda

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Drug Profile

Mobocertinib - Takeda

Alternative Names: AP 32788; EXKIVITY; Exkivity; Mobocertinib succinate - Takeda; TAK 788

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator ARIAD Pharmaceuticals
  • Developer ARIAD Pharmaceuticals; Takeda
  • Class Amides; Antineoplastics; Dimethylamines; Esters; Ethers; Indoles; Pyrimidines; Small molecules
  • Mechanism of Action BLK protein inhibitors; Epidermal growth factor receptor antagonists; ERBB 2 receptor antagonists; ERBB 4 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer

Most Recent Events

  • 11 Oct 2023 Updated pharmacodynamics and adverse events data from a phase I/II in NSCLC presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 2023 (AACR-NCI-EORTC-2023)
  • 02 Oct 2023 Withdrawn for Non-small cell lung cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO)
  • 02 Oct 2023 Takeda plans to withdraw Mobocertinib for the treatment of Non-small cell lung cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in all the countries where it is currently registered no later than March 2024

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