MVT 1075

Drug Profile

MVT 1075

Alternative Names: 177Lu Human Monoclonal Antibody 5B1; 177Lu- CHX-A″-DTPA-HuMAb-5B1; 177Lu-DTPA-HuMab-5B; 90Y- CHX-A″-DTPA-HuMAb-5B1; HuMab 5B1 radioimmunotherapy agent - MabVax; HuMab-5B1 conjugated Actinium225-radioimmunotherapy agent; MVT 1916; MVT-1075; radiolabeled HuMab 5B1 antibody - MabVax

Latest Information Update: 07 Mar 2018

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At a glance

  • Originator MabVax Therapeutics
  • Developer MabVax Therapeutics; Memorial Sloan-Kettering Cancer Center
  • Class Antibodies; Antineoplastics; Immunoconjugates; Immunotherapies; Monoclonal antibodies; Radiopharmaceuticals
  • Mechanism of Action Ionising radiation emitters
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Colorectal cancer; Lung cancer; Pancreatic cancer

Most Recent Events

  • 28 Feb 2018 Interim adverse events data from a phase I trial in Pancreatic cancer released by MabVax Therapeutics
  • 18 Dec 2017 MabVax Therapeutics completes enrolment in its phase I trial for Pancreatic, Colorectal and Lung cancer (NCT03118349)
  • 27 Jun 2017 Phase-I clinical trials in Colorectal cancer (Combination therapy, Second-line therapy or greater, Metastatic disease, Late-stage disease) in USA (Parenteral)
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