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Nemtabrutinib - Merck

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Drug Profile

Nemtabrutinib - Merck

Alternative Names: ARQ-531; MK-1026

Latest Information Update: 04 Mar 2026

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At a glance

  • Originator ArQule
  • Developer Merck & Co
  • Class Antineoplastics; Pyrimidines; Pyrroles; Small molecules
  • Mechanism of Action Agammaglobulinaemia tyrosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Chronic lymphocytic leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Chronic lymphocytic leukaemia
  • Phase II Follicular lymphoma; Haematological malignancies; Richter's syndrome

Most Recent Events

  • 04 Mar 2026 Efficacy and adverse event data from the phase II BELLWAVE-003 trial in Follicular lymphoma presented at the 67th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2025)
  • 08 Dec 2025 Merck Sharp & Dohme initiates phase I trial (In volunteers) in USA (PO) (NCT07232589)
  • 06 Dec 2025 Efficacy and adverse event data from the phase III BELLWAVE-010 trial in Chronic lymphocytic leukaemia presented at the 67th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2025)

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