Drug Profile

Noribogaine - DemeRx

Alternative Names: 12-hydroxy-ibogamine; 12-OH-ibogamine; DMX-1001

Latest Information Update: 14 Oct 2025

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At a glance

Originator DemeRx
Class Alkaloids; Analgesics; Small molecules
Mechanism of Action NMDA receptor antagonists; Opioid receptor antagonists; Serotonin uptake inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

08 Oct 2025 DemeRx plans phase-II clinical trials in Alcoholism
13 Jan 2025 DemeRx completes phase-I clinical trials in Alcoholism (In volunteers) in United Kingdom (PO) (NCT06480981)
20 Jun 2024 Phase-I clinical trials in Alcoholism (In volunteers) in United Kingdom (PO) (NCT06480981)

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