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Endoxifen - Atossa Therapeutics

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Drug Profile

Endoxifen - Atossa Therapeutics

Alternative Names: (Z)-endoxifen; Z-endoxifen - Atossa Therapeutics

Latest Information Update: 14 Aug 2026

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At a glance

  • Originator Atossa Genetics
  • Developer Atossa Therapeutics; Weill Cornell Medicine
  • Class Antineoplastics; Methylamines; Phenyl ethers; Small molecules; Stilbenes
  • Mechanism of Action Protein kinase C beta inhibitors; Selective estrogen receptor degraders
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Duchenne muscular dystrophy
  • New Molecular Entity No

Highest Development Phases

  • Phase II Breast cancer; Ductal carcinoma; HER2 negative breast cancer
  • Preclinical Duchenne muscular dystrophy; Endometrial cancer; Triple negative breast cancer
  • No development reported Gynaecomastia; Ovarian cancer

Most Recent Events

  • 30 Jun 2026 Atossa Therapeutics completes enrollment in the phase II EVANGELINE trial in HER2-negative-breast-cancer (Neoadjuvant therapy) in USA (PO, Capsule) (NCT05607004)
  • 02 Jun 2026 Pharmacodynamics data from preclinical studies in Breast cancer presented at the (2026 American Society of Clinical Oncology (ASCO) Annual Meeting
  • 06 May 2026 Efficacy and adverse events data from the phase II KARISMA Endoxifen trial in Breast cancer released by Atossa Therapeutics

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