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Endoxifen - Atossa Therapeutics

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Drug Profile

Endoxifen - Atossa Therapeutics

Alternative Names: (Z)-endoxifen

Latest Information Update: 17 Jun 2025

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At a glance

  • Originator Atossa Genetics
  • Developer Atossa Therapeutics; Weill Cornell Medicine
  • Class Antineoplastics; Methylamines; Phenyl ethers; Small molecules; Stilbenes
  • Mechanism of Action Estrogen receptor antagonists; Selective estrogen receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II Breast cancer; Ductal carcinoma; HER2 negative breast cancer
  • Preclinical Triple negative breast cancer
  • No development reported Gynaecomastia; Ovarian cancer

Most Recent Events

  • 25 Apr 2025 Atossa Therapeutics plans a phase III SMART 2.0 registrational trial for Breast cancer (Prevention) (PO)
  • 25 Mar 2025 Efficacy and adverse events data from phase II trial for Breast Cancer released by Atossa Therapeutics
  • 10 Dec 2024 Updated efficacy, adverse events and pharmacokinetics data from the phase II EVANGELINE trial in HER2-negative-breast-cancer trial presented at the 47th Annual San Antonio Breast Cancer Symposium (SABCS-2024)

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