Tiragolumab - Genentech
Alternative Names: anti-TIGIT - Roche; MTIG-7192A; RG-6058; RG6058-10; RG6058-11; RO 7092284Latest Information Update: 13 Aug 2025
At a glance
- Originator Genentech
- Developer Chugai Pharmaceutical; Genentech; National Cancer Institute (USA); Roche; Washington University School of Medicine
- Class Antineoplastics; Immunotherapies; Monoclonal antibodies
- Mechanism of Action Antibody-dependent cell cytotoxicity; T lymphocyte stimulants; TIGIT protein inhibitors
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Discontinued B-cell lymphoma; Cervical cancer; Gastric cancer; Liver cancer; Malignant melanoma; Multiple myeloma; Non-small cell lung cancer; Oesophageal cancer; Rectal cancer; Renal cell carcinoma; Small cell lung cancer; Solid tumours; Squamous cell cancer; Triple negative breast cancer; Urogenital cancer
Most Recent Events
- 24 Jul 2025 Discontinued - Phase-I/II for Liver cancer (First-line therapy, Combination therapy, Metastatic disease, Late-stage disease) in USA (IV)
- 24 Jul 2025 Discontinued - Phase-I/II for Liver cancer (Neoadjuvant therapy, Combination therapy) in USA (IV)
- 24 Jul 2025 Discontinued - Phase-II for Non-small cell lung cancer (Neoadjuvant therapy, Adjuvant therapy, Combination therapy, First-line therapy, Inoperable/Unresectable, Late-stage disease) in USA (IV)