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Tiragolumab - Genentech

Drug Profile

Tiragolumab - Genentech

Alternative Names: anti-TIGIT - Roche; MTIG-7192A; RG-6058; RG6058-10; RG6058-11; RO 7092284

Latest Information Update: 09 May 2024

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At a glance

  • Originator Genentech
  • Developer Chugai Pharmaceutical; Genentech; National Cancer Institute (USA); Roche; Washington University School of Medicine
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; T lymphocyte stimulants; TIGIT protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Liver cancer; Non-small cell lung cancer; Oesophageal cancer
  • Phase II Cervical cancer; Gastric cancer; Malignant melanoma; Rectal cancer; Renal cell carcinoma; Small cell lung cancer; Solid tumours; Squamous cell cancer; Urogenital cancer
  • Phase I/II B-cell lymphoma
  • No development reported Multiple myeloma; Triple negative breast cancer

Most Recent Events

  • 09 May 2024 Phase- I development is ongoing in Solid-tumours (Late-stage disease, Metastatic disease, Combination therapy) in South Korea, France, Canada, Spain, Japan, Australia (IV) (NCT02794571) (Roche pipeline, May 2024)
  • 09 May 2024 Roche plans regulatory filings in Liver cancer (First line therapy, Combination therapy) in or after 2027 (Roche pipeline, May 2024)
  • 09 May 2024 Roche plans to file a regulatory application for Squamous cell cancer (Combination therapy, First-line therapy, Metastatic disease, Recurrent) in or after 2027 (Roche pipeline, May 2024)
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