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Tiragolumab - Genentech

Drug Profile

Tiragolumab - Genentech

Alternative Names: anti-TIGIT - Roche; MTIG-7192A; RG-6058; RG6058-10; RG6058-11; RO 7092284

Latest Information Update: 09 Jul 2024

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At a glance

  • Originator Genentech
  • Developer Chugai Pharmaceutical; Genentech; National Cancer Institute (USA); Roche; Washington University School of Medicine
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; T lymphocyte stimulants; TIGIT protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Liver cancer; Non-small cell lung cancer; Oesophageal cancer
  • Phase II Cervical cancer; Gastric cancer; Malignant melanoma; Rectal cancer; Renal cell carcinoma; Small cell lung cancer; Solid tumours; Squamous cell cancer; Triple negative breast cancer; Urogenital cancer
  • Phase I/II B-cell lymphoma
  • No development reported Multiple myeloma

Most Recent Events

  • 04 Jul 2024 Roche plans to submit data from a phase II/III SKYSCRAPER-06 trial in Non-small cell lung cancer to regulatory authorities
  • 04 Jul 2024 Efficacy and adverse events data from a phase II/III SKYSCRAPER-06 trial in Non-small cell lung cancer released by Roche
  • 12 Jun 2024 Phase-II clinical trials in Triple-negative-breast-cancer (Combination therapy, Second-line therapy or greater, Late-stage disease, Metastatic disease) in Netherlands (IV) (NCT06342037)
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