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Vutrisiran - Alnylam Pharmaceuticals

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Drug Profile

Vutrisiran - Alnylam Pharmaceuticals

Alternative Names: ALN-65492; ALN-TTRsc02; AMVUTTRA

Latest Information Update: 18 Aug 2026

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At a glance

  • Originator Alnylam Pharmaceuticals
  • Class Amides; Amino sugars; Drug conjugates; Small interfering RNA
  • Mechanism of Action Prealbumin expression inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Transthyretin-related hereditary amyloidosis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Transthyretin-related hereditary amyloidosis

Most Recent Events

  • 30 Jul 2026 Vutrisiran licensed to BeOne Medicines in China and Macau for the treatment of Transthyretin-related-hereditary-amyloidosis
  • 30 Jul 2026 Launched for Transthyretin-related hereditary amyloidosis in Spain (SC)
  • 02 Mar 2026 Canada's Drug Agency (CDA) gives positive recommendation for Vutrisiran in Transthyretin-related hereditary amyloidosis

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