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Luxeptinib - Aptose Biosciences/CrystalGenomics

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Drug Profile

Luxeptinib - Aptose Biosciences/CrystalGenomics

Alternative Names: CG-026806; CG-806

Latest Information Update: 23 Mar 2025

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At a glance

  • Originator CrystalGenomics
  • Developer Aptose Biosciences; CrystalGenomics
  • Class Antineoplastics; Fluorobenzenes; Imidazoles; Isoindoles; Phenylurea compounds; Small molecules
  • Mechanism of Action Agammaglobulinaemia tyrosine kinase inhibitors; Apoptosis stimulants; Aurora kinase inhibitors; Discoidin domain receptor 2 antagonists; Extracellular signal-regulated MAP kinase inhibitors; Fms-like tyrosine kinase 3 inhibitors; Interleukin 6 inhibitors; Lyn protein-tyrosine kinase inhibitors; NLRP3 protein inhibitors; Platelet-derived growth factor alpha receptor antagonists; Proto-oncogene protein c-akt inhibitors; Proto-oncogene protein c-ret inhibitors; Src-family kinase inhibitors; Syk kinase inhibitors; Tumour necrosis factor alpha inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Acute myeloid leukaemia; Chronic lymphocytic leukaemia; Myelodysplastic syndromes; Non-Hodgkin's lymphoma
  • Preclinical Haematological malignancies; Mantle-cell lymphoma

Most Recent Events

  • 05 Mar 2025 Aptose Biosciences terminates a phase I clinical trials in Myelodysplastic syndromes in USA (PO) due to change in corporate strategy (NCT04477291)
  • 05 Mar 2025 Aptose Biosciences terminates phase-I clinical trials in Chronic lymphocytic leukaemia (Second-line therapy or greater) and Non-Hodgkin's lymphoma (Second-line therapy or greater) in USA (PO) due change in corporate strategy (NCT03893682)
  • 06 Jun 2024 Luxeptinib is still in phase-I development in Chronic-lymphocytic-leukaemia (Second-line therapy or greater), Acute myeloid leukaemia (Second-line therapy or greater), Myelodysplastic syndromes, Non-Hodgkin's lymphoma (Second-line therapy or greater) in USA (PO, Capsule)

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