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Nivatrotamab - Y-mAbs Therapeutics

Drug Profile

Nivatrotamab - Y-mAbs Therapeutics

Alternative Names: Hu3F8 bispecific antibody - Y-mAbs Therapeutics; Hu3F8-BsAb (GD2xCD3); huGD2-BsAb

Latest Information Update: 21 Jul 2022

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At a glance

  • Originator Memorial Sloan-Kettering Cancer Center
  • Developer Memorial Sloan-Kettering Cancer Center; Y-mAbs Therapeutics
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Neuroblastoma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Neuroblastoma; Osteosarcoma; Small cell lung cancer; Solid tumours
  • No development reported Ewing's sarcoma

Most Recent Events

  • 08 Apr 2022 Y-mAbs Therapeutics terminates a phase I/II trial in Small cell lung cancer (Metastatic disease, Second-line therapy or greater, Recurrent) in USA due to business priorities (SC) (NCT04750239)
  • 20 Oct 2021 Y-mAbs Therapeutics terminates phase I/II trial in Osteosarcoma (In adolescents, In adults, In children, In the elderly, Second-line therapy or greater) in USA (IV) (NCT03860207)
  • 16 Aug 2021 Phase-I/II clinical trials in Small cell lung cancer (Metastatic disease, Second-line therapy or greater, Recurrent) in USA (SC) (NCT04750239)
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