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Ezurpimtrostat - Genoscience

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Drug Profile

Ezurpimtrostat - Genoscience

Alternative Names: GNS-561

Latest Information Update: 14 May 2024

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At a glance

  • Originator Genoscience
  • Developer Genfit; Genoscience
  • Class Antifibrotics; Antineoplastics; Antivirals; Chlorinated hydrocarbons; Piperidines; Quinolines; Small molecules
  • Mechanism of Action Apoptosis stimulants; Autophagy inhibitors; PPT1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cholangiocarcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Cancer; COVID 2019 infections; Liver cancer
  • Phase I/II Cholangiocarcinoma
  • No development reported Hepatic fibrosis

Most Recent Events

  • 08 Mar 2024 Grenoble University Hospital in collaboration with Genoscience terminates a phase II trial in Liver cancer (Metastatic disease, First-line therapy, Inoperable/Unresectable) in France (PO) due to recruitement issues (NCT05448677)
  • 28 Dec 2023 No recent reports of development identified for preclinical development in Cholangiocarcinoma in France
  • 28 Dec 2023 No recent reports of development identified for preclinical development in Hepatic-fibrosis in France (Intraperitoneal, Injection)

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