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VX 522

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Drug Profile

VX 522

Alternative Names: mRNA-3692; VX-522; VXc-0522; VXc-522

Latest Information Update: 14 Jul 2025

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At a glance

  • Originator Moderna Therapeutics; Vertex Pharmaceuticals
  • Developer Vertex Pharmaceuticals
  • Class Antifibrotics; RNA
  • Mechanism of Action Cystic fibrosis transmembrane conductance regulator expression stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Cystic fibrosis

Most Recent Events

  • 14 Jul 2025 Vertex Pharmaceuticals terminates a phase-I/II clinical trials in Cystic fibrosis in USA, Australia, Belgium, Canada, Germany, Italy, Netherlands, Spain, Sweden, United Kingdom (Inhalation) due to sponsor decision (NCT05668741)
  • 03 Feb 2025 Phase-I/II clinical trials in Cystic fibrosis in USA, Australia, Belgium, Canada, Germany, Italy, Netherlands, Spain, Sweden, United Kingdom (Inhalation) (NCT05668741)
  • 06 Jan 2023 Phase-I clinical trials in Cystic fibrosis in USA (Inhalation) (NCT05668741)

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