CDX 014

Drug Profile

CDX 014

Alternative Names: CDX-014; CR 014-vcMMAE

Latest Information Update: 17 May 2018

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At a glance

  • Originator Amgen; CuraGen Corporation
  • Developer Celldex Therapeutics Inc
  • Class Antineoplastics; Immunoconjugates; Monoclonal antibodies
  • Mechanism of Action Membrane protein inhibitors; T cell activation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Ovarian cancer; Renal cell carcinoma

Most Recent Events

  • 17 May 2018 Discontinued - Phase-I/II for Ovarian cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (Parenteral)
  • 17 May 2018 Discontinued - Phase-I/II for Renal cell carcinoma (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (Parenteral)
  • 07 Mar 2018 Celldex Therapeutics has a patent pending for CDX 014 in Japan
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