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NT 219

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Drug Profile

NT 219

Alternative Names: NT-219

Latest Information Update: 28 May 2026

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At a glance

  • Originator Hebrew University of Jerusalem
  • Developer Purple Biotech; TyrNovo
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Insulin receptor substrate protein inhibitors; STAT3 transcription factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I/II Colorectal cancer; Solid tumours; Squamous cell cancer
  • Discontinued Malignant melanoma

Most Recent Events

  • 31 Dec 2025 NT 219 is available for licensing as of 31 Dec 2025. https://purple-biotech.com/
  • 17 Oct 2025 Discontinued - Preclinical for Malignant melanoma in Israel (unspecified route) (Purple Biotech pipeline, October 2025)
  • 10 Sep 2025 The Examining Division of the European Patent Office issues an intention to grant a European Patent for NT 219 combinations with immunotherapies or MEK inhibitors to overcome tumour resistance

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