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MRX 2843

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Drug Profile

MRX 2843

Alternative Names: MRX-2843

Latest Information Update: 16 Aug 2024

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At a glance

  • Originator University of North Carolina at Chapel Hill
  • Developer Emory University; Meryx; National Cancer Institute (USA)
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Fms-like tyrosine kinase 3 inhibitors; Receptor protein-tyrosine kinase antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Acute biphenotypic leukaemia; Acute myeloid leukaemia; Non-small cell lung cancer; Precursor cell lymphoblastic leukaemia-lymphoma; Solid tumours
  • No development reported Haematological malignancies

Most Recent Events

  • 14 Aug 2024 MRX 2843 is still in phase-I clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO) (NCT03510104) (Betta Pharmaceuticals pipeline, August 2024)
  • 21 Jun 2024 MRX 2843 is still in phase I trial for Non-small cell lung cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO) (NCT04762199)
  • 05 Apr 2024 Pharmacodynamics data from a preclinical trial in Non-small cell lung cancer presented at the 115th Annual Meeting of the American Association for Cancer Research (AACR-2024)

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