Drug Profile

Pegipanermin - INmune Bio

Alternative Names: DN-TNF; INB-03; LIVNate™; Quellor™; Soluble tumour necrosis factor inhibitor; XENP1595; XENP345; XPro 1595; XPro595; XPro^TM

Latest Information Update: 17 Jun 2025

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At a glance

Originator Emory University; Xencor
Developer Alzheimer's Association; Emory University; FPRT Bio; INmune Bio; Xencor
Class Anti-inflammatories; Antidementias; Antidepressants; Antineoplastics; Antiparkinsonians; Hepatoprotectants; Polyethylene glycols; Recombinant proteins
Mechanism of Action Immunostimulants; Tumour necrosis factor alpha inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes
Available For Licensing Yes

Phase II Alzheimer's disease; Major depressive disorder; Mild cognitive impairment
Preclinical HER2 positive breast cancer
No development reported Neurodegenerative disorders; Non-alcoholic steatohepatitis; Solid tumours
Discontinued COVID-19 respiratory infection; Parkinson's disease

10 Jun 2025 Pharmacodynamics data from a preclinical trial in Alzheimer's disease released by INmune Bio
08 May 2025 INmune Bio plans a phase II trial for Major depressive disorder (Treatment-resistant) once NIH funding is available
30 Sep 2024 INmune Bio completes enrolment in its phase II trial for Alzheimer's disease (In the elderly) in US, Germany, Poland, the Czech Republic, Slovakia, Australia, United Kingdom, Spain, France, and Canada (NCT05318976)

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