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Pegipanermin - INmune Bio

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Drug Profile

Pegipanermin - INmune Bio

Alternative Names: DN-TNF; INB-03; LIVNate™; Quellor™; Soluble tumour necrosis factor inhibitor; XENP1595; XENP345; XPro 1595; XPro595; XProTM

Latest Information Update: 14 Aug 2026

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At a glance

  • Originator Emory University; Xencor
  • Developer Alzheimer's Association; Emory University; FPRT Bio; INmune Bio; Xencor
  • Class Anti-inflammatories; Antidementias; Antidepressants; Antineoplastics; Antiparkinsonians; Hepatoprotectants; Polyethylene glycols; Recombinant proteins
  • Mechanism of Action Immunostimulants; Tumour necrosis factor alpha inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Alzheimer's disease; Mild cognitive impairment; Treatment-resistant depressive disorder
  • Preclinical HER2 positive breast cancer
  • No development reported Neurodegenerative disorders; Non-alcoholic steatohepatitis; Solid tumours
  • Discontinued COVID-19 respiratory infection; Parkinson's disease

Most Recent Events

  • 07 Aug 2026 INmunre Bio plans to submit phase IIb/III protocol in Alzhiemer's disease to USFDA in fourth quarter of 2026
  • 20 Jul 2026 Pharmacodynamics data from a phase II MINDFuL trial in Alzheimer's-disease released by INmune Bio
  • 15 Jul 2026 Pharmacodynamics data from a preclinical trial in Alzheimer's disease released by INmune Bio

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