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Pegipanermin - INmune Bio

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Drug Profile

Pegipanermin - INmune Bio

Alternative Names: DN-TNF; INB-03; LIVNate™; Quellor™; Soluble tumour necrosis factor inhibitor; XENP1595; XENP345; XPro 1595; XPro595; XProTM

Latest Information Update: 16 Feb 2026

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At a glance

  • Originator Emory University; Xencor
  • Developer Alzheimer's Association; Emory University; FPRT Bio; INmune Bio; Xencor
  • Class Anti-inflammatories; Antidementias; Antidepressants; Antineoplastics; Antiparkinsonians; Hepatoprotectants; Polyethylene glycols; Recombinant proteins
  • Mechanism of Action Immunostimulants; Tumour necrosis factor alpha inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Alzheimer's disease; Mild cognitive impairment; Treatment-resistant depressive disorder
  • Preclinical HER2 positive breast cancer
  • No development reported Neurodegenerative disorders; Non-alcoholic steatohepatitis; Solid tumours
  • Discontinued COVID-19 respiratory infection; Parkinson's disease

Most Recent Events

  • 12 Feb 2026 INmune Bio announces FDA alignment on integrated phase IIb/III registration pathway for XPro1595 in Early Alzheimer’s Disease
  • 12 Feb 2026 INmune Bio received the official minutes from its End-of-Phase II (Type B) meeting with the US FDA
  • 12 Feb 2026 INmune Bio plans to initiate a phase IIb/III trial for XPro1595 for Alzheimer’s Disease

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