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Pegipanermin - INmune Bio

Drug Profile

Pegipanermin - INmune Bio

Alternative Names: DN-TNF; INB-03; LIVNate™; Quellor™; Soluble tumour necrosis factor inhibitor; XENP1595; XENP345; XPro 1595; XPro595; XProTM

Latest Information Update: 06 Feb 2024

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At a glance

  • Originator Emory University; Xencor
  • Developer Alzheimer's Association; Emory University; FPRT Bio; INmune Bio; Xencor
  • Class Anti-inflammatories; Antidementias; Antidepressants; Antineoplastics; Antiparkinsonians; Hepatoprotectants; Polyethylene glycols; Recombinant proteins
  • Mechanism of Action Immunostimulants; Tumour necrosis factor alpha inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alzheimer's disease; Major depressive disorder; Mild cognitive impairment
  • Preclinical HER2 positive breast cancer
  • No development reported Neurodegenerative disorders; Non-alcoholic steatohepatitis; Solid tumours
  • Discontinued COVID-19 respiratory infection; Parkinson's disease

Most Recent Events

  • 30 Jan 2024 INmune Bio plans an end-of-phase II meeting with US FDA for planned global Phase III trial in Alzheimer's disease in early 2025
  • 30 Jan 2024 The US FDA lifts the full clinical hold on the Alzheimer's disease clinical trial program
  • 30 Jan 2024 INmune Bio plans a global phase III trial for Alzheimer's disease in the US, Canada, the UK, the European Union and Pacific Rim
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