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Efineptakin alfa - Genexine

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Drug Profile

Efineptakin alfa - Genexine

Alternative Names: Efineptakin alfa NT-I7; GX I7; HyLeukin; HyLeukin-7™; IL-7 Hybrid Fc; IL-7-hyFc; Interleukin-7-hybrid-Fc-recombinant-protein; NT I7; Recombinant human IL-7-hyFc; Recombinant human interleukin-7 hybrid Fc; rhIL-7 - Genexine/NovaBridge Biosciences; rhIL-7-hyFc; TJ 107

Latest Information Update: 11 Nov 2025

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At a glance

  • Originator Genexine
  • Developer Bristol-Myers Squibb; Fred Hutchinson Cancer Research Center; Genexine; Merck & Co; National Cancer Institute (USA); National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; NeoImmuneTech; NovaBridge Biosciences; PT Kalbe Genexine Biologics; Roche; Yonsei University
  • Class Antineoplastics; Antivirals; Immunoglobulin Fc fragments; Immunotherapies; Interleukins; Radioprotectives; Recombinant fusion proteins; Recombinant proteins
  • Mechanism of Action Interleukin 7 replacements; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma; Idiopathic CD4-positive T-lymphocytopenia; Acute radiation syndrome; Pancreatic cancer; Progressive multifocal leukoencephalopathy
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Adenocarcinoma; COVID 2019 infections; Glioblastoma; Head and neck cancer; Non-small cell lung cancer; Squamous cell cancer; Triple negative breast cancer
  • Phase I/II Lymphopenia; Pancreatic cancer; Skin cancer; Small cell lung cancer; Solid tumours
  • Preclinical Acute radiation syndrome
  • No development reported Anal cancer; Biliary cancer; Bladder cancer; Breast cancer; Cervical cancer; Cervical intraepithelial neoplasia; Colorectal cancer; Diffuse large B cell lymphoma; Human papillomavirus infections; Idiopathic CD4-positive T-lymphocytopenia; Kaposi's sarcoma; Lymphoma; Ovarian cancer; Progressive multifocal leukoencephalopathy

Most Recent Events

  • 30 Oct 2025 I-MAB Biopharma is now called NovaBridge Biosciences
  • 07 Oct 2025 Washington University School of Medicine plans a phaseI trial for Multiple myeloma (Second line therapy or greater) in USA (IM) in January 2026 (NCT07200089)
  • 04 Jul 2025 Washington University School of Medicine plans a phase I trial for Diffuse large B cell lymphoma (Second-line therapy or greater) in USA (IM, injection) in October 2025 (NCT07052305)

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