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Efineptakin alfa - Genexine

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Drug Profile

Efineptakin alfa - Genexine

Alternative Names: Efineptakin alfa NT-I7; GX I7; HyLeukin; HyLeukin-7™; IL-7 Hybrid Fc; IL-7-hyFc; Interleukin-7-hybrid-Fc-recombinant-protein; NT I7; Recombinant human IL-7-hyFc; Recombinant human interleukin-7 hybrid Fc; rhIL-7 - Genexine/I-MAB Biopharma; rhIL-7-hyFc; TJ 107

Latest Information Update: 12 Aug 2024

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At a glance

  • Originator Genexine
  • Developer Bristol-Myers Squibb; Fred Hutchinson Cancer Research Center; Genexine; I-MAB Biopharma; Merck & Co; National Cancer Institute (USA); National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; NeoImmuneTech; PT Kalbe Genexine Biologics; Roche; Yonsei University
  • Class Antineoplastics; Antivirals; Immunoglobulin Fc fragments; Immunotherapies; Interleukins; Radioprotectives; Recombinant fusion proteins; Recombinant proteins
  • Mechanism of Action Interleukin 7 replacements; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma; Idiopathic CD4-positive T-lymphocytopenia; Acute radiation syndrome; Pancreatic cancer; Progressive multifocal leukoencephalopathy
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Adenocarcinoma; COVID 2019 infections; Glioblastoma; Head and neck cancer; Non-small cell lung cancer; Squamous cell cancer; Triple negative breast cancer
  • Phase I/II Lymphopenia; Pancreatic cancer; Skin cancer; Small cell lung cancer; Solid tumours
  • Phase I Anal cancer; Biliary cancer; Cervical cancer; Diffuse large B cell lymphoma; Kaposi's sarcoma; Ovarian cancer
  • Preclinical Acute radiation syndrome
  • No development reported Bladder cancer; Breast cancer; Cervical intraepithelial neoplasia; Colorectal cancer; Human papillomavirus infections; Idiopathic CD4-positive T-lymphocytopenia; Lymphoma; Progressive multifocal leukoencephalopathy

Most Recent Events

  • 09 Aug 2024 Phase-I/II clinical trials in Lymphopenia in USA (IM) (NCT05600920)
  • 28 Jun 2024 No recent reports of development identified for phase-I development in Progressive multifocal leukoencephalopathy in USA (IM, Injection)
  • 04 Jun 2024 Efineptakin alfa - Genexine receives Orphan Drug status for Acute radiation syndrome in Europe

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